Time-Resolved Enthalpy and Volume Changes for Co-Photorelease from Indoleamine 2,3-Dioxygenase

Indoleamine 2,3-Dioxygenase and Immunological Tolerance during Pregnancy

Indoleamine 2,3-dioxygenase (IDO), an enzyme involved in the catabolism of tryptophan, is expressed by a variety of cells and tissues such as macrophages, dendritic cells, cells of the endocrine system and by the placenta. IFN- γ is the main inducer of this enzyme. IDO acts as an important defense mechanism of innate immunity against pathogens. It also has tumor suppressive activity and prolong...

Indoleamine 2,3-Dioxygenase Mediates Cell

Indoleamine 2,3-dioxygenase (ido) and Immune Tolerance

The IDO facilitates immune tolerance and is one of the main actors involved in the inhibition of cell proliferation, including activated T cells. IDO induces production of reactive oxygen species (ROS) and nitric oxide (NO) radicals. Several pathways involved in the regulation of immune response are regulated by redox mechanisms. Reactive oxygen and nitrogen species (ROSRNS) and other redox act...

Indoleamine 2,3-dioxygenase and tumor-induced tolerance.

Tumors arise from normal cells of the body through genetic mutation. Although such genetic mutation often leads to the expression of abnormal antigens, the immune system fails to respond effectively to these antigens; that is, it is tolerant of these antigens. This acquired state of tolerance must be overcome for cancer immunotherapy to succeed. Indoleamine 2,3-dioxygenase (IDO) is one molecula...

Indoleamine 2,3-dioxygenase: From tolerance during pregnancy to cancer

RESUMEN El feto expresa durante el embarazo antígenos procedentes del padre que no provocan el rechazo como cualquier otro injerto semi-alogénico. Entre los sistemas implicados en la inducción de la tolerancia materno-fetal, se encuentra la enzima indolamina 2,3-dioxigenasa (IDO) que inicia la degradación del triptófano. Al consumir el triptófano provoca una inhibición de la respuesta de las cé...